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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2AK4
All Species:
18.18
Human Site:
T1282
Identified Species:
40
UniProt:
Q9P2K8
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9P2K8
NP_001013725.2
1649
186838
T1282
N
S
L
I
K
Q
K
T
G
I
A
Q
L
V
K
Chimpanzee
Pan troglodytes
XP_001140245
1649
186793
T1282
N
S
L
I
K
Q
K
T
G
I
A
Q
L
V
K
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_535431
1633
184740
T1284
N
S
L
I
K
Q
K
T
G
V
A
Q
L
V
K
Cat
Felis silvestris
Mouse
Mus musculus
Q9QZ05
1648
186468
T1281
N
S
L
I
K
Q
K
T
G
V
A
Q
L
V
K
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518247
1608
180821
S1241
N
Q
V
A
T
Q
K
S
G
V
A
Q
L
V
K
Chicken
Gallus gallus
XP_421203
1656
188583
P1288
N
T
M
I
K
Q
K
P
G
V
T
Q
L
L
K
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_002667149
1483
168725
L1152
S
V
V
P
E
D
K
L
T
H
A
S
N
I
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_001120977
1130
130476
P799
K
W
P
I
V
V
V
P
L
L
V
H
N
V
N
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_785160
1605
181469
S1272
V
P
E
E
L
H
G
S
L
Y
R
T
L
N
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LX30
1241
140303
V910
T
E
A
E
V
L
K
V
I
V
D
I
T
T
H
Baker's Yeast
Sacchar. cerevisiae
P15442
1659
190175
K1264
I
D
S
P
H
L
K
K
I
E
D
S
L
S
H
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
N.A.
89.7
N.A.
90.5
N.A.
N.A.
74.7
72.3
N.A.
52.6
N.A.
N.A.
27.9
N.A.
40.4
Protein Similarity:
100
99.9
N.A.
94.3
N.A.
94.9
N.A.
N.A.
84.4
84.5
N.A.
67.4
N.A.
N.A.
44
N.A.
59.4
P-Site Identity:
100
100
N.A.
93.3
N.A.
93.3
N.A.
N.A.
60
60
N.A.
13.3
N.A.
N.A.
13.3
N.A.
13.3
P-Site Similarity:
100
100
N.A.
100
N.A.
100
N.A.
N.A.
80
86.6
N.A.
40
N.A.
N.A.
20
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
22.5
26.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
39.7
46.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
10
10
0
0
0
0
0
0
55
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
10
0
0
0
10
0
0
0
0
19
0
0
0
0
% D
% Glu:
0
10
10
19
10
0
0
0
0
10
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
10
0
55
0
0
0
0
0
0
% G
% His:
0
0
0
0
10
10
0
0
0
10
0
10
0
0
19
% H
% Ile:
10
0
0
55
0
0
0
0
19
19
0
10
0
10
0
% I
% Lys:
10
0
0
0
46
0
82
10
0
0
0
0
0
0
64
% K
% Leu:
0
0
37
0
10
19
0
10
19
10
0
0
73
10
10
% L
% Met:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
55
0
0
0
0
0
0
0
0
0
0
0
19
10
10
% N
% Pro:
0
10
10
19
0
0
0
19
0
0
0
0
0
0
0
% P
% Gln:
0
10
0
0
0
55
0
0
0
0
0
55
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% R
% Ser:
10
37
10
0
0
0
0
19
0
0
0
19
0
10
0
% S
% Thr:
10
10
0
0
10
0
0
37
10
0
10
10
10
10
0
% T
% Val:
10
10
19
0
19
10
10
10
0
46
10
0
0
55
0
% V
% Trp:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _